Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and H2O quantification
نویسندگان
چکیده
Kristian K. Jensen,* Stephen F. Previs,* Lei Zhu, Kithsiri Herath, Sheng-Ping Wang, Gowri Bhat, Guanghui Hu, Paul L. Miller, David G. McLaren, Myung K. Shin, Thomas F. Vogt, Liangsu Wang, Kenny K. Wong, Thomas P. Roddy, Douglas G. Johns, and Brian K. Hubbard Departments of Atherosclerosis, Exploratory and Translational Sciences, and Informatics and Analysis, Merck Research Laboratories, Rahway, New Jersey
منابع مشابه
Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification.
The liver is a crossroad for metabolism of lipid and carbohydrates, with acetyl-CoA serving as an important metabolic intermediate and a precursor for fatty acid and cholesterol biosynthesis pathways. A better understanding of the regulation of these pathways requires an experimental approach that provides both quantitative metabolic flux measurements and mechanistic insight. Under conditions o...
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